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The Saito group [146] employed high-fat diet-induced obese mice and genetically obese ob/ob mice as experimental models and found that malonyl-CoA levels were elevated in obese tissues, where malonyl-CoA binds to the Rossmann fold domain of C-terminal binding protein 2 (CtBP2), facilitating the interaction between CtBP2 and PPAR

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IGF-1 binds to receptors on muscle cells and promotes cell growth and division through autocrine signaling